Lightyellow Sophora Root kǔ shēn · 苦参

Safety. Contains matrine and related quinolizidine alkaloids, which have measurable pharmacological activity; published case literature documents liver injury and cardiac adverse events in connection with improper or prolonged use. Not for long-term use. Listed among the herbs traditionally incompatible with Veratrum (藜芦). Avoid in pregnancy and breastfeeding — animal data raise concern and human data are lacking.