Source 出处 · Xiaoer Yao Zheng Zhi Jue · Doses are not given here: they are set by a licensed practitioner for the individual.
Safety. Xie Qing Wan is recorded in Xiaoer Yao Zheng Zhi Jue. Seven ingredients: angelica root, gentian root, ligusticum rhizome, gardenia fruit, rhubarb, notopterygium rhizome and saposhnikovia root. Green is the colour the tradition assigns to wood and to the liver, so the name says plainly which organ the formula is aimed at; the companion formula that drains the yellow drains the spleen.
Two disambiguations come before anything else. First, this is not Long Dan Xie Gan Tang. The two share gentian and gardenia, but they are different formulas with different compositions, and the confusion is worth heading off because Long Dan Xie Gan Tang carries its own modern safety history: batches in which the mu tong ingredient was supplied as Aristolochia manshuriensis caused aristolochic acid nephropathy and later urothelial carcinoma, the cluster reported in Belgium in the 1990s, after which that aristolochia-containing form was prohibited and replaced. Xie Qing Wan contains no mu tong of any kind. The two names are close enough that a reader who has heard the aristolochic acid story deserves to be told which formula it attaches to, and which it does not.
Second, it contains rhubarb. Rhubarb is an anthraquinone stimulant laxative. With prolonged use that means dependence, potassium loss that compounds with diuretics and with digoxin, cramping, and the brown pigmentation of the bowel wall seen at endoscopy. It is the reason this is not a formula to take indefinitely, and it is one more reason it is not a formula for undiagnosed abdominal pain.
What the source aims it at is depressive liver fire: red and painful eyes, irritability, and in children fright-wind and convulsions. Both of those warrant a modern sentence, and the second warrants a loud one.
Convulsions in a child are an emergency pathway. Nothing in this entry is a way of managing one. The differential includes febrile seizure, epilepsy, intracranial infection such as meningitis and encephalitis, electrolyte disturbance including low sodium, calcium and magnesium, hypoglycaemia, head injury, breath-holding spells and syncope, and toxic ingestion. The classical text was written before electroencephalography, lumbar puncture and bedside glucose measurement existed. A child who has had a seizure needs to be assessed, and a first febrile seizure is a reason to be seen even when the child looks entirely well afterwards. Never give anything by mouth, including any herbal liquid, to a child who is not fully awake, because a swallowing reflex that is not intact turns a drink into an aspiration.
A red, painful eye is not liver fire until the alternatives are excluded. Conjunctivitis is common and usually benign. But uveitis brings pain, photophobia and reduced acuity and needs same-day ophthalmology; acute angle-closure glaucoma presents with severe pain, blurred vision with haloes around lights, vomiting and a fixed mid-dilated pupil, and damages the optic nerve within hours; scleritis and orbital cellulitis are urgent; and proptosis with double vision needs imaging. Any red eye with reduced vision, severe pain or a pupil that looks wrong should be treated as urgent rather than as something to cool.
The herbs: angelica root contains furanocoumarins, which photosensitise, and laboratory work reports antiplatelet activity, so caution is reasonable with warfarin and antiplatelet drugs and before surgery; it is also widely sold for women's health on an evidence base that is genuinely mixed, and this library reports it as mixed. Ligusticum rhizome has similar laboratory signals around platelets. Gentian is intensely bitter, and several Gentiana species are under wild-collection pressure. Notopterygium is likewise wild-collected and has been under pressure in its Chinese range. Gardenia carries the same limited-evidence liver note described under Xie Huang San. The pill form is bound with honey, which is a carbohydrate load and, again, never for an infant under twelve months.
This library does not claim that this formula stops seizures, clears the eye or treats any disease.
泻青丸著录于《小儿药证直诀》。七味：当归、龙胆草、川芎、栀子、大黄、羌活、防风。青是传统配给木、配给肝的颜色，方名因此直说了它所对的是哪一脏；泻黄散泻脾，本方泻肝，两方以颜色成对。
有两处辨析要放在最前面。其一，本方**不是**龙胆泻肝汤。两方共有龙胆草与栀子，但是组成不同的两首方；之所以要先说开，是因为龙胆泻肝汤有它自己那一段现代安全史：其中木通一味曾被以关木通（Aristolochia manshuriensis）投料的批次，导致了马兜铃酸肾病与随后的尿路上皮癌，即 1990 年代比利时报告的那一组病例；此后含马兜铃酸的那一来源被禁用并替换。**泻青丸不含任何木通。** 两个方名近到足以混淆，听过马兜铃酸这件事的读者应当知道它挂在哪个方上、不挂在哪个方上。
其二，本方含大黄。大黄是蒽醌类刺激性泻药：久用意味着依赖、失钾（与利尿剂及地高辛叠加）、腹痛，以及肠镜下可见的结肠黑变病。这正是本方不宜久服的理由，也是它不适用于未判明病因之腹痛的又一重理由。
原文所对的是肝经郁火：目赤肿痛、急躁易怒，以及小儿惊风抽搐。这两项今天都各值得一句，第二项值得大声说。
**小儿抽搐是急诊路径。** 本条里没有任何内容可用于处置一次抽搐。鉴别包含热性惊厥、癫痫、颅内感染（脑膜炎、脑炎）、电解质紊乱（低钠、低钙、低镁）、低血糖、颅脑外伤、屏气发作与晕厥、以及中毒。古典文本成书于脑电图、腰穿与床旁血糖之前。抽搐过的小儿需要评估；首次热性惊厥尤其需要在事后就诊，即使孩子看上去已经完全如常。**意识不完全清醒者，不得经口喂任何东西（含汤药）** —— 吞咽反射不完整时，一口东西会变成误吸。
红痛的眼睛，在排除其他之前不是「肝火」。结膜炎常见且多良性；但葡萄膜炎（眼痛、畏光、视力下降）需要当日眼科；**急性闭角型青光眼**表现为剧烈眼痛、视物模糊并见灯光周围有虹圈、呕吐、瞳孔中等散大而固定，并以小时计地损害视神经；巩膜炎与眶蜂窝织炎属急症；突眼伴复视需要影像检查。任何伴视力下降、剧痛或瞳孔异常的红眼，都应按急症处理，而不是当作需要清一清的东西。
几味药：当归含呋喃香豆素（光敏），实验室研究报告抗血小板活性，与华法林、抗血小板药同用及术前以谨慎为宜；它也被广泛用于女性健康领域，而证据基础是确实混杂的，本库照实写混杂。川芎有相近的实验室信号。龙胆草极苦，且数种龙胆属植物面临野生采挖压力。羌活同为野生采挖，在国内分布区长期承压。栀子的肝脏关注与泻黄散条下所写相同，人体证据有限。丸剂以蜜为赋形，既是糖负荷，也再一次意味着一岁以下婴儿不宜。
本库不声称本方能止抽、明目或治疗任何疾病。